Mother-to-child transmission (MTCT) of human immunodeficiency virus is the largest route of transmission of this virus in children below the age of 15 years. Despite decades of sensitization and significant advances in its prevention and management, the pandemic continues to spread as an estimated 2 million global new HIV infections were recorded in 2019. The study investigated the outcome of nurse-led intervention on prevention of mother to child transmission of HIV among pregnant women attending antenatal clinic in selected primary health care centres in Osogbo, Osun State. This study utilized one group pre-test and post-test quasi experimental design. The study population comprised of pregnant women attending antenatal clinics at three selected primary health care centres in Osogbo, Osun State. The sample size of 253 was obtained from the population using Cochran formula. An instrument tagged test paper on knowledge of pregnant women on HIV was used for data collection. The instrument was validated by experts of Nursing Science and Tests & Measurement while reliability coefficient was 0.73. Data collection was carried out in three phases namely: pre-intervention phase, intervention phase and post-intervention phase while the data collected was subjected to descriptive and inferential statistics. The result of the findings revealed that the knowledge of prevention of mother-to-child transmission of HIV/AIDS at pre-test was moderate (51.2%) while it was good (100%) after intervention. It was concluded that the nurse-led intervention programme improved knowledge on prevention of mother-to-child transmission of HIV/AIDS. It was, therefore, recommended among others that educational intervention regarding prevention of mother-to-child transmission is required during the period of antenatal and postnatal visit.

Keywords:  Outcome, Nurse-Led Intervention, Prevention, Mother-To-Child Transmission, HIV/AIDS, Pregnant Women,

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