Compassion fatigue is a pervasive challenge in medical-surgical nursing, posing risks to both nurse well-being and patient care quality. Defined as the emotional, physical, and psychological exhaustion resulting from prolonged exposure to patient suffering, compassion fatigue affects an estimated 20–40% of nurses, leading to emotional detachment, reduced work engagement, and increased turnover. The Compassion Fatigue Resilience Framework (CFR) was developed to address this issue through a comprehensive, nurse-centered approach that integrates psychological resilience, self-care strategies, social support, and organizational policies. Grounded in Stress and Coping Theory, Resilience Theory, Self-Determination Theory, and the Biopsychosocial Model, the CFR emphasizes proactive resilience-building to maintain empathy, professional efficacy, and mental well-being. Multimodal interventions, including mindfulness, cognitive-behavioral therapy, reflective practice, peer support, mentorship, and organizational wellness initiatives, are operationalized to reduce fatigue and enhance adaptive coping. Pilot testing, revision, and validation processes ensure its feasibility, cultural adaptability, and theoretical rigor across diverse clinical settings. By combining individual, interpersonal, and systemic strategies, the CFR offers a structured framework to sustain nurse resilience, improve patient outcomes, and promote workforce retention. Its implementation represents a proactive, evidence-based approach to mitigating compassion fatigue in high-stress medical-surgical environments.

Keywords: Compassion fatigue, resilience, medical-surgical nursing, nurse well-being, organizational support, mindfulness interventions,

Cite this article: